Relief from endo pain could be a reality
What is Myfembree?
What are the benefits of Myfembree?
Myfembree was studied and proven effective in two 6-month clinical studies in a total of 1,251 premenopausal women with moderate to severe endometriosis pain.
Myfembree reduced pain during sex by 43% in women who engaged in sex at the start of and during the studies‡
Painful sex is a common symptom of endo, making sexual relationships a challenge for many women.
Women taking Myfembree experienced an overall improvement in the impact that endo pain had on their daily activities
In studies, women were asked how often their endo pain made them unable to engage in daily activities in the last 4 weeks (eg, attend a social event, do jobs around the house, sitting, exercising, sleeping). Women taking Myfembree reported an overall improvement in the impact that endo pain had on their daily activities.
An improvement in pain within 2 period cycles
While the studies were not specifically designed to determine how quickly Myfembree worked, some of the women started seeing an improvement in period pain at 2 months.
*At week 24, compared with 3 out of 10 women on placebo. †At week 24, compared with 4 out of 10 women on placebo. ‡At week 24 compared with a 29% reduction on placebo.
Understanding Possible Side Effects
In clinical trials, the safety of Myfembree was also studied.
The most common side effects
The most common side effects of taking Myfembree for moderate to severe endometriosis pain were headache; hot flushes, sweating, or night sweats; mood changes, including worsening depression; abnormal vaginal bleeding (bleeding that lasts too long, that is too heavy, or is unexpected); nausea; toothache; back pain; decreased interest in sex; joint pain; tiredness; and dizziness.
Serious side effects
Serious side effects were reported in 2.9% of women on Myfembree and 2.2% of women on placebo. Serious side effects were uterine hemorrhage, suicidal ideation, gallstones, and gallbladder inflammation.
In clinical trials, 4.5% of women treated with Myfembree stopped taking it because of side effects, compared with 2.9% of women in the placebo group. The most common side effect that led to discontinuation for women taking Myfembree was mood-related disorders (1.7%).
These are not all the possible side effects of Myfembree.
How does Myfembree work?
Myfembree is made of 3 key ingredients, designed to support an optimal hormone range that promotes a reduction of endometriosis pain.
Relugolix may reduce the amount of estrogen (and other hormones) produced by the body, helping to alleviate endo pain.
Estradiol (an estrogen)
Estradiol may reduce the risk of bone loss that may be caused by taking relugolix alone.
Norethindrone acetate (a progestin)
Norethindrone acetate may protect the uterus from the effect of taking estrogen alone.