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Less bleeding, same life? I'll take it.
Meet Myfembree, a proven treatment to reduce heavy menstrual bleeding due to uterine fibroids in premenopausal women.
Myfembree should not be taken for more than 24 months.
See what Myfembree can doWhat Is Myfembree?
Myfembree is a small (8 mm in diameter), once-daily prescription pill. It’s designed to support an optimal hormone range that promotes a reduction in heavy period bleeding from uterine fibroids in premenopausal women.
- Relugolix, which may reduce the amount of estrogen (and other hormones) in your body to help reduce menstrual bleeding
- Estradiol (an estrogen), which may reduce the risk of bone loss caused by taking relugolix alone
- Norethindrone acetate (a progestin), which may protect the uterus from the effect of taking estrogen alone
Myfembree should not be taken for more than 24 months.
Proven Results
Myfembree was studied in two 6-month clinical trials that included a total of 768 premenopausal women, to establish whether it reduced heavy menstrual bleeding due to uterine fibroids.
By week 24, average menstrual bleeding with Myfembree was reduced by 84%—a reduction almost 5x greater than placebo*
Additionally, 7 out of 10 women† saw their bleeding drop by at least half AND to a normal level‡ or less by the last month of treatment.
- On average, before starting the study, women had bleeding 3 times the normal amount of a typical period‡
- Compared with an average 17% reduction of blood loss in the placebo group.
- Compared with 16% of women in the placebo group.
- Normal bleeding is defined as 80 mL (about 1/3 cup) or less.
- Compared with an average 17% reduction of blood loss in the placebo group.
- Compared with 16% of women in the placebo group.
- Normal bleeding is defined as 80 mL (about 1/3 cup) or less.
It’s very important to start Myfembree as soon as possible after your period begins, and no later than 7 days after it has started. Otherwise, your period may become heavy or irregular for the first month of treatment, but bleeding should decrease over time.
Understanding Side Effects
The clinical trials also looked at the safety of Myfembree.
Most common side effects
The most common side effects of Myfembree include hot flushes, increased sweating, night sweats, abnormal vaginal bleeding (bleeding that lasts too long, is too much, or is unexpected), hair loss or hair thinning, and decreased interest in sex. Always tell your doctor if you experience a side effect that bothers you or will not go away.
Serious side effects
Serious side effects were reported in 3.1% of women on Myfembree vs. 2.3% on placebo. Fibroid expulsion with heavy bleeding, fibroid prolapse, gallbladder inflammation, and pelvic pain were experienced by one patient each across both studies.
Discontinuations
In clinical trials, about 4% of women treated with Myfembree stopped taking Myfembree as a result of side effects, which was similar to women in the placebo group. The most common side effect that led to discontinuation was uterine bleeding (1.2%), occurring usually within the first 3 months of treatment.
These are not all the possible side effects of Myfembree.
Ready to talk with your doctor about Myfembree?
Take a moment to think about how heavy period bleeding due to uterine fibroids has been affecting you.
The downloadable Discussion Guide can help you start a convo with your doctor about treatment, and give them a better picture of how bleeding is affecting you.
Cost & Support
The Myfembree® Support Program may help people prescribed Myfembree with coverage needs.
No insurance, or if you have received a denial
The Myovant Patient Assistance Program can provide Myfembree at no cost to eligible people with a coverage denial or no insurance coverage.
The Myovant Patient Assistance Program can provide a supply of Myfembree as long as a person can meet and maintain eligibility requirements. This free medication supply is fulfilled by TC Script, a noncommercial dispensing pharmacy.
Have questions about enrollment?
Call to speak with a dedicated support staff member who will guide you through the enrollment process
1-833-MYFEMBREE (1-833-693-3627)Monday–Friday, 8 AM-8 PM ET
USE
Myfembree is used to control heavy menstrual bleeding due to uterine fibroids in premenopausal women ≥18 years of age. It should not be taken for more than 24 months.
IMPORTANT SAFETY INFORMATION
Boxed Warning. Cardiovascular conditions: Myfembree may increase your chances of heart attack, stroke, or blood clots, especially if you are >35 and smoke or have uncontrolled high blood pressure. Stop taking Myfembree and call your healthcare provider (HCP) or go to the nearest emergency room right away if you have: leg pain or swelling that won’t go away; sudden shortness of breath; double vision, bulging of the eyes, sudden partial or complete blindness; pain or pressure in your chest, arm, or jaw; sudden, severe headache unlike your usual headaches; weakness or numbness in an arm or leg, or trouble speaking.
IMPORTANT SAFETY INFORMATION
Boxed Warning. Cardiovascular conditions: Myfembree may increase your chances of heart attack, stroke, or blood clots, especially if you are >35 and smoke or have uncontrolled high blood pressure. Stop taking Myfembree and call your healthcare provider (HCP) or go to the nearest emergency room right away if you have: leg pain or swelling that won’t go away; sudden shortness of breath; double vision, bulging of the eyes, sudden partial or complete blindness; pain or pressure in your chest, arm, or jaw; sudden, severe headache unlike your usual headaches; weakness or numbness in an arm or leg, or trouble speaking.
USE
Myfembree is used to control heavy menstrual bleeding due to uterine fibroids in premenopausal women ≥18 years of age. It should not be taken for more than 24 months.
USE
Myfembree is used to control heavy menstrual bleeding due to uterine fibroids in premenopausal women ≥18 years of age. It should not be taken for more than 24 months.
IMPORTANT SAFETY INFORMATION
Boxed Warning. Cardiovascular conditions: Myfembree may increase your chances of heart attack, stroke, or blood clots, especially if you are >35 and smoke or have uncontrolled high blood pressure. Stop taking Myfembree and call your healthcare provider (HCP) or go to the nearest emergency room right away if you have: leg pain or swelling that won’t go away; sudden shortness of breath; double vision, bulging of the eyes, sudden partial or complete blindness; pain or pressure in your chest, arm, or jaw; sudden, severe headache unlike your usual headaches; weakness or numbness in an arm or leg, or trouble speaking.
Do not take Myfembree if you:
- have or have had blood clots in your legs, lungs, or eyes; a stroke or heart attack; a problem that makes your blood clot more than normal; blood circulation disorders; certain heart valve or rhythm problems that can cause blood clots to form in the heart; high blood pressure not well controlled by medicine; diabetes with kidney, eye, nerve, or blood vessel damage; certain kinds of severe migraine headaches with aura, numbness, weakness or changes in vision or migraine headaches if you are >35 years old; breast cancer or any cancer that is sensitive to female hormones; osteoporosis; undiagnosed vaginal bleeding; liver problems;
- smoke and are >35 years old;
- have had a serious allergic reaction (e.g., swelling of your face, lips, mouth or tongue, trouble breathing, skin rashes, redness) or swelling or an allergic reaction to relugolix, estradiol, norethindrone or any of the ingredients in Myfembree.
Bone loss (decreased bone mineral density [BMD]). While taking Myfembree, your estrogen levels may be low, which can lead to BMD loss. If this happens, your BMD may improve after you stop Myfembree, but complete recovery may not occur. It is unknown if these BMD changes could increase your risk for broken bones as you age. For this reason, you should not take Myfembree for more than 24 months. Your HCP may order an X-ray test called a DXA scan to check your BMD when you start Myfembree and periodically after.
Suicidal thoughts and behavior and worsening of mood. Call your HCP or get emergency medical help right away if you have any of these symptoms, especially if they are new, worse, or bother you: thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, other unusual changes in behavior or mood. Pay attention to any changes, especially sudden changes in your mood, behaviors, thoughts, or feelings.
Abnormal liver tests. Call your HCP right away if you have any of these signs and symptoms of liver problems: jaundice, dark, amber-colored urine, feeling tired, nausea and vomiting, generalized swelling, right upper stomach area pain, bruising easily.
High blood pressure. See your HCP to check your blood pressure regularly.
Effects on pregnancy. Do not take Myfembree if you are trying to become or are pregnant. It may increase the risk of early pregnancy loss. If you think you are pregnant, stop taking Myfembree right away and call your HCP. Myfembree can cause decreased or no menstrual bleeding, making it hard to know if you are pregnant. Watch for other signs of pregnancy like breast tenderness, weight gain, and nausea. Myfembree does not prevent pregnancy. You will need to use effective non-hormonal methods of birth control (e.g., condoms, spermicide) during and for 1 week after stopping Myfembree. Do not take hormonal birth control such as birth control pills, because they may increase side effects and Myfembree may not work as well.
Uterine fibroid prolapse or expulsion. Fibroids can come out completely or partially through the vagina. Call your HCP right away if you have increased bleeding from the vagina, which can be serious, or cramping.
Severe allergic reactions. Myfembree may cause swelling of your face, lips, mouth or tongue, trouble breathing, skin rashes, and redness.
Most common side effects are hot flushes, increased sweating, night sweats, abnormal vaginal bleeding, hair loss or thinning, and decreased interest in sex.
These are not all the possible side effects of Myfembree. Call your doctor for medical advice about side effects.
Tell your HCP about all your prescription and over-the-counter medicines, vitamins, and herbal supplements. If you take oral P-gp inhibitors, take Myfembree first and wait at least 6 hours before taking the P-gp inhibitor. Ask your HCP if you are not sure if you are taking this type of medicine.
Tell your HCP if you are breastfeeding. Myfembree may pass into your breast milk.
Please see full Prescribing Information, including BOXED WARNING and Patient Information